Cambridge University EPIC-Norfolk
  EPIC-Norfolk: Publications
(with selected papers relating to the international EPIC study)


For all papers, the button provides a direct link to the relevant journal, where available. The journal website will generally show the abstract.

The button links to a full text version of a paper, if one is available. All of the full text links will work if you have a IP address, but some may not work from other institutions. Some of the full text versions are in Adobe Acrobat format.

For books, the button links to the entry.

Clicking on the button takes you to our page giving futher details of selected papers.


A Perez-Cornago, PN Appleby, H Boeing, L Gil, C Kyro, F Ricceri, N Murphy, A Trichopoulou, KK Tsilidis, K Khaw, RN Luben, RE Gislefoss, H Langseth, I Drake, E Sonestedt, P Wallstrom, Par Stattin, A Johansson, R Landberg, L Nilsson, K Ozasa, A Tamakoshi, K Mikami, T Kubo, N Sawada, S Tsugane, TJ Key, NE Allen, RC Travis. (2018) Circulating isoflavone and lignan concentrations and prostate cancer risk: A meta-analysis of individual participant data from seven prospective studies including 2828 cases and 5593 controls. Int J Cancer ():.

C Kyro, R Zamora-Ros, A Scalbert, A Tjonneland, L Dossus, C Johansen, P Bidstrup, E Weiderpass, J Christensen, H Ward, D Aune, E Riboli, M His, F Clavel-Chapelon, L Baglietto, V Katzke, T Kuhn, H Boeing, A Floegel, Kim Overvad, C Lasheras, N Travier, M Sanchez, P Amiano, M Chirlaque, Eva Ardanaz, K Khaw, N Wareham, A Perez-Cornago, A Trichopoulou, P Lagiou, E Vasilopoulou, G Masala, S Grioni, F Berrino, R Tumino, C Sacerdote, A Mattiello, B Bueno-de-Mesquita, PH Peeters, C van Gils, S Borgquist, S Butt, A Zeleniuch-Jacquotte, M Sund, A Hjartaaker, G Skeie, A Olsen, I Romieu. (2015) Pre-diagnostic polyphenol intake and breast cancer survival: the {Europe}an Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Breast Cancer Res Treat 154 (2):389-401.

AA Mulligan, GGC Kuhnle, MAH Lentjes, V van Scheltinga, NA Powell, A McTaggart, A Bhaniani, K Khaw. (2013) Intakes and sources of isoflavones, lignans, enterolignans, coumestrol and soya-containing foods in the Norfolk arm of the {Europe}an Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk), from 7 d food diaries, using a newly updated database. Public Health Nutr 16 (8):1454-1462.

R Swann, KA Perkins, LS Velentzis, C Ciria, SJ Dutton, AA Mulligan, JV Woodside, MM Cantwell, AJ Leathem, CE Robertson, MV Dwek. (2013) The DietCompLyf study: a prospective cohort study of breast cancer survival and phytoestrogen consumption. Maturitas 75 (3):232-240.

R Zamora-Ros, V Knaze, L Lujan-Barroso, GGC Kuhnle, AA Mulligan, M Touillaud, N Slimani, I Romieu, N Powell, R Tumino, PHM Peeters, de Magistris, F Ricceri, E Sonestedt, I Drake, A Hjartaaker, G Skie, T Mouw, PA Wark, D Romaguera, H Bueno-de-Mesquita, M Ros, E Molina, S Sieri, JR Quiros, JM Huerta, A Tjonneland, J Halkjaer, G Masala, B Teucher, R Kaas, RC Travis, V Dilis, V Benetou, A Trichopoulou, P Amiano, E Ardanaz, H Boeing, J Forster, F Clavel-Chapelon, G Fagherazzi, F Perquier, G Johansson, I Johansson, A Cassidy, K Overvad, CA Gonzalez. (2012) Dietary intakes and food sources of phytoestrogens in the {Europe}an Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. Eur J Clin Nutr ():.

GGC Kuhnle, HA Ward, A Vogiatzoglou, RN Luben, A Mulligan, NJ Wareham, NG Forouhi, K Khaw. (2011) Association between dietary phyto-oestrogens and bone density in men and postmenopausal women. Br J Nutr ():1-7.

HA Ward, GGC Kuhnle. (2010) Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfolk. Arch Biochem Biophys 501 (1):170-175.

HA Ward, GGC Kuhnle, AA Mulligan, MAH Lentjes, RN Luben, K Khaw. (2010) Breast, colorectal, and prostate cancer risk in the {Europe}an Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. Am J Clin Nutr 91 (2):440-448.

GGC Kuhnle, C Dellaquila, Sue Aspinall, SA Runswick, AA Mulligan, SA Bingham. (2009) Phytoestrogen content of cereals and cereal-based foods consumed in the UK. Nutr Cancer 61 (3):302-309.

S Bingham, R Luben, A Welch, Y Low, K Khaw, N Wareham, N Day. (2008) Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study. Int J Epidemiol ():.

H Ward, G Chapelais, GGC Kuhnle, R Luben, K Khaw, S Bingham. (2008) Lack of Prospective Associations between Plasma and Urinary Phytoestrogens and Risk of Prostate or Colorectal Cancer in the {Europe}an Prospective into Cancer-Norfolk Study. Cancer Epidemiol Biomarkers Prev 17 (10):2891-2894.

H Ward, G Chapelais, GGC Kuhnle, R Luben, K Khaw, S Bingham, Prospective European. (2008) Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the {Europe}an Prospective into Cancer-Norfolk cohort study. Breast Cancer Res 10 (2):R32.

AA Welch, SA Bingham, KT Khaw. (2008) Estimated conversion of alpha-linolenic acid to long chain n-3 polyunsaturated fatty acids is greater than expected in non fish-eating vegetarians and non fish-eating meat-eaters than in fish-eaters. J Hum Nutr Diet 21 (4):404.

GGC Kuhnle, C DellAquila, Sue Aspinall, SA Runswick, AA Mulligan, SA Bingham. (2008) Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafood. J Agric Food Chem 56 (21):10099-10104.

GGC Kuhnle, C DellAquila, Sue Aspinall, SA Runswick, AA Mulligan, SA Bingham. (2008) Phytoestrogen content of beverages, nuts, seeds, and oils. J Agric Food Chem 56 (16):7311-7315.

M Verheus, CH van Gils, L Keinan-Boker, PB Grace, SA Bingham, PHM Peeters. (2007) Plasma phytoestrogens and subsequent breast cancer risk. J Clin Oncol 25 (6):648-655.

PHM Peeters, N Slimani, YT van der Schouw, PB Grace, C Navarro, A Tjonneland, A Olsen, F Clavel-Chapelon, M Touillaud, M Boutron-Ruault, M Jenab, R Kaaks, J Linseisen, A Trichopoulou, D Trichopoulos, V Dilis, H Boeing, C Weikert, Kim Overvad, V Pala, D Palli, S Panico, R Tumino, P Vineis, Bueno-de-Mesquita Bas, CH van Gils, G Skeie, P Jakszyn, G Hallmans, G Berglund, Tim Key, R Travis, E Riboli, SA Bingham. (2007) Variations in plasma phytoestrogen concentrations in {Europe}an adults. J Nutr 137 (5):1294-1300.

AA Mulligan, AA Welch, AA McTaggart, A Bhaniani, SA Bingham. (2007) Intakes and sources of soya foods and isoflavones in a UK population cohort study (EPIC-Norfolk). Eur J Clin Nutr 61 (2):248-254.

GGC Kuhnle, C Dellaquila, Y Low, M Kussmaul, SA Bingham. (2007) Extraction and quantification of phytoestrogens in foods using automated solid-phase extraction and {LC}/MS/MS. Anal Chem 79 (23):9234-9239.

Y Low, AM Dunning, M Dowsett, E Folkerd, D Doody, J Taylor, A Bhaniani, R Luben, K Khaw, NJ Wareham, SA Bingham. (2007) Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants. Cancer Epidemiol Biomarkers Prev 16 (5):1009-1016.

Y Low, JI Taylor, PB Grace, AA Mulligan, AA Welch, S Scollen, AM Dunning, RN Luben, K Khaw, NE Day, NJ Wareham, SA Bingham. (2006) Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutr Cancer 56 (1):31-39.

A Welch, S Bingham, J Camus, N Dalzell, J Reeve, N Day, KT Khaw. (2005) Calcaneum broadband ultrasound attenuation relates to vegetarian and omnivorous diets differently in men and women: an observation from the {Europe}an Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study. Osteoporos Int 16 (6):590-596.

G Nagel, U Mack, von Fournier, J Linseisen. (2005) Dietary phytoestrogen intake and mammographic density -- results of a pilot study. Eur J Med Res 10 (9):389-394.

Y Low, JI Taylor, PB Grace, M Dowsett, E Folkerd, D Doody, AM Dunning, S Scollen, AA Mulligan, AA Welch, RN Luben, K Khaw, NE Day, NJ Wareham, SA Bingham. (2005) Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men. J Nutr 135 (11):2680-2686.

Y Low, JI Taylor, PB Grace, M Dowsett, S Scollen, AM Dunning, AA Mulligan, AA Welch, RN Luben, K Khaw, NE Day, NJ Wareham, SA Bingham. (2005) Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in {Europe}an Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. Cancer Epidemiol Biomarkers Prev 14 (1):213-220.

L Keinan-Boker, YT van Der Schouw, DE Grobbee, PHM Peeters. (2004) Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr 79 (2):282-288.

PB Grace, JI Taylor, Y Low, RN Luben, AA Mulligan, NP Botting, M Dowsett, AA Welch, K Khaw, NJ Wareham, NE Day, SA Bingham. (2004) Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in {Europe}an prospective investigation of cancer and nutrition-norfolk. Cancer Epidemiol Biomarkers Prev 13 (5):698-708.

AA Mulligan, RN Luben, AA Welch, SA Bingham. (2002) Daidzein and genistein intakes in {England} (the EPIC Norfolk cohort). IARC Sci Publ 156 ():369-370.

PK Verkasalo, PN Appleby, NE Allen, G Davey, H Adlercreutz, TJ Key. (2001) Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the {Europe}an Prospective Investigation into Cancer and Nutrition). Br J Nutr 86 (3):415-421.