epicnorfolk – Page 2

Genetic markers for intraocular pressure may improve risk prediction for primary open-angle glaucoma

18 May 2018

Summary

Glaucoma is the leading cause of irreversible blindness in the world. Raised intraocular pressure (IOP) is the most important modifiable risk factor for primary open-angle glaucoma (POAG). Yet the mechanism underling IOP regulation is not yet understood. Prior to our study, genome-wide association studies (GWAS) had identified only a few genetic markers associated with IOP, explaining a tiny proportion of its variability.

We carried out a GWAS for IOP in over 100,000 European participants and identified 112 independent loci associated with IOP. These genetic markers explained 17% of the variance of IOP, which is huge considering the daily variation in IOP in individuals and measurement error which affects IOP readings. [Read more…]

Mediterranean diet could lower the risk of cardiovascular disease in the UK

29 September 2016

Britons eating a Mediterranean diet could lower their risk of developing cardiovascular disease including conditions such as heart attack and stroke, according to EPIC Norfolk research published in the open access journal BMC Medicine.

In this study, the first of its kind carried out in a UK population, the researchers found that healthy individuals with greater adherence to a Mediterranean-type diet had about an 11% lower risk of future cardiovascular disease compared to individuals who had poor adherence. The work was led by PhD student Tammy Tong, together with colleagues Dr Fumiaki Imamura, Professor Nicholas Wareham, Professor Kay-Tee Khaw, and Dr Nita Forouhi. [Read more…]

Study at Cambridge

About the University

Research at Cambridge